Restoring Life's Potential

with Innovative Solutions for the Treatment of Nerve Damage

About NervGen

NervGen is a publicly traded (TSX-V: NGEN, OTCQX: NGENF) clinical stage biotech company dedicated to discovering and developing treatments for patients suffering from medical conditions related to nerve damage.

NervGen’s core technology targets protein tyrosine phosphatase sigma (PTPσ), a neural receptor that impedes nerve regeneration, remyelination and plasticity. Inhibition of the PTPσ receptor has been shown to promote regeneration of damaged nerves and improvement of nerve function in animal models for various indications.

Our lead product is NVG-291 which we are planning to develop for multiple sclerosis, Alzheimer’s disease, and spinal cord injury.

NVG-291 entered Phase 1 clinical trials in the first half of 2021.

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Our Technology

Our technology was developed in the laboratory of Dr. Jerry Silver, a renowned spinal cord injury and regenerative medicine researcher and Professor of Neurosciences at Case Western Reserve University (CWRU) in Cleveland, Ohio.

Dr. Silver’s research focuses on the glial scar which forms at sites of a physical injury such as spinal cord injury, as well as sites of inflammatory damage from neurodegenerative diseases.

Dr. Silver and his collaborators were able to discover a constituent in scars that is a major inhibitor of the body’s natural ability to regrow and regenerate, and the key neural receptor that binds to the constituent to inhibit nerve regeneration, known as protein tyrosine phosphatase sigma (PTPσ).

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Latest News

NervGen Pharma Announces Intent to Conduct Groundbreaking Spinal Cord Injury Clinical Trial in Exclusive Partnership with Shirley Ryan AbilityLab, #1-Ranked Hospital in Physical Medicine & Rehabilitation

January 10, 2022

The NervGen Story

In this inspiring & heartfelt video, Dr. Jerry Silver, Professor of Neurosciences, Case Western Reserve University, shares his journey and how the research carried out in his lab led to the formation of NervGen.

The video highlights how NervGen is developing Dr. Silver’s foundational discoveries into a disruptive technology that is aimed at changing the paradigm of how nervous system damage will be treated.